In the last years has been studied new formulations using textile materials for drug delivery. In this sense, my
main line of research is development of new nanotechnology formulation containing natural product for
treatment of chronic venous insufficiency, impregnated into textile fibers as a possible alternative treatment of
- Validation of analytical methods
- Pharmaceutical technology
- Physicochemical characterization
- Drug delivery
- Textile materials
- Wound healing
- Skin diseases
- 3D bioprinting
- Tissue engineering
Some natural products have a pharmacological effects such as antioxidant, anti-inflammatory, antiplatelet and vasoprotective. However, in plants, the metabolites have low solubility. In this context, the incorporation of these potential molecules in nanoparticles, can improve your solubility, bioavailability and stability. Furthermore, these formulations can be vehicled in platforms as textile materials with aim of controlled drug delivery from the fabric to the skin with local action.
Cyclodextrins are molecules with hydrophobic cavity and hydrophilic surface capable of to form inclusion complexes with molecules of low molecular weight as terpenes and essential oils. The inclusion phenomena improves the physicochemical characteristics of the drug and enhanced your pharmacological profile.
The species diversity of plants results in a multitude of secondary metabolites with diverse chemical structures, which have played, and will continue to play, a vital role in the drug discovery and development process. Indeed, the diversity of plant-based systems has provided an enormous number of lead compounds in healthcare.
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