Grace Anne A. Dória, Anderson R. Santos, Leonardo S. Bittencourt, Rafael C. Bortolin, Paula P. Menezes , Bruno S. Vasconcelos, Rebeca O. Souza, Maria José V. Fonseca, Alan Diego C. Santos, Shanmugam Saravanan, Francilene A. Silva, Daniel P. Gelain, José Cláudio F. Moreira, Ana Paula N. Prata, Lucindo J. Quintans-Júnior and Adriano A. S. Araújo
Molecules, Volume 20, Issue 7, Pages 11699-11718
Publication year: 2015

Abstract: Remirea maritima is a tropical plant with a reticulated root system belonging
to the family Cyperaceae, also known to have biologically active secondary metabolites.
However, very few data on R. maritima’s biological actions are available and there are no reports regarding the redox-active profile of this plant. In this study, we examined the total
phenolic content of Remirea maritima hydroalcoholic (RMHA) extracts, redox properties
against different reactive species generated in vitro and their cytotoxic effect against
fibroblasts (L929) and melanoma (B16F10) cells. Total reactive antioxidant potential
index (TRAP) and total antioxidant reactivity (TAR) results revealed that RMHA at all
concentrations tested showed significant antioxidant capacity. RMHA was also effective
against hydroxyl radical formation, reduction of Fe3+ to Fe2+ and in scavenging nitric oxide
(NO) radicals. In vitro, the level of lipid peroxidation was reduced by RMHA extract and
the data showed significant oxidative damage protection. The RMHA cytotoxicity was
evaluated by a neutral red assay in fibroblast (L929) and melanome (B16F10) cells. The
obtained results showed that the RMHA (40 and 80 μg/mL, respectively) reduced 70% of the
viable cells. In conclusion, this study represents the first report regarding the antioxidant and
anti-proliferative potential of R. maritima against B16F10 melanoma cells.

Keywords: Remirea maritima; free radicals; cellular viability; oxidative stress; cytotoxicity;
total phenol

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