Grace Anne A. Dória, Paula P. Menezes, Bruno S.Lima, Bruno S. Vasconcelos, Francilene A. Silva, Raíssa M. Henriques, Marcélia G. D. Meloa Ângela V. F. Alves, Manoel O. Moraes, Cláudia Ó Pessoa, Adriana A. Carvalho, Ana Paula N. Prata, Ricardo Luiz C. A. Junior, Isabel B. Lima-Verde, Lucindo J. Quintans-Júnior, Daniel P. Bezerra, Paulo C. L. Nogueira, Adriano A. S. Araujo
Phytomedicine Volume 23, Issue 9, 15 August 2016, Pages 914-922
Publication year: 2016



Remirea maritima has been widely used in the treatment of diarrhea, kidney disease, and high fever and for therapeutic purposes, such as an analgesic and anti-inflammatory. However, few scientific research studies on its medicinal properties have been reported.


The present study aimed to investigate the anticancer potential of aqueous extract (AE), 40% hydroalcoholic extracts (40HA) and 70% (70HA) from R. maritima in experimental models and to identify its phytochemical compounds.


The chemical composition of AE, 40HA and 70HA was assessed by HPLC-DAD and ESI-IT-MS/MS. In vitro activity was determined on cultured tumor cell, NCI-H385N (Broncho-alveolar carcinoma), OVCAR-8 (Ovarian carcinoma) and PC-3 M (prostate carcinoma) by the MTT assay, and the in vivo antitumor activity was assessed in Sarcoma 180-bearing mice. Toxicological parameters were also evaluated as well as the humoral immune response.


Among the aqueous and hydroalcoholic extracts of R. maritima, only 40HA showed in vitro biological effect potential, presenting IC50 values of 27.08, 46.62 and > 50 µg/ml for OVCAR-8, NCI-H385M and PC-3 M cells lines, respectively. Regarding chemical composition, a mixture of isovitexin-2′′-O-β-D-glucopyranoside, vitexin-2′′-O-β-D-glucopyranoside, luteolin-7-O-glucuronide and 1-O-(E)-caffeoyl-β-D-glucose were identified as the major phytochemical compounds of the extracts. In the in vivo study, the tumor inhibition rates were 57.16–62.57% at doses of 25 mg/kg and 50 mg/kg, respectively, and the tumor morphology presented increasing numbers of apoptotic cells. Additionally, 40HA also demonstrated significantly increased of OVA-specific total Ig.


40HA exhibited in vitro and in vivo anticancer properties without substantial toxicity that could be associated with its immunostimulating properties.

Deixe uma resposta

O seu endereço de email não será publicado. Campos obrigatórios marcados com *

They dry quickly. To fill your lace front wigs uk with warm water, add a capful of, let sit 10 minutes and rinse. Empty sink and refill with warm lace wigs uk and then add a capful of conditioner. Let air dry on stand. Only wash once per week maximum. You will love this hair. Nice beautiful quality. The hair extensions was a little smaller than expected but I have a small head so it worked out just fine. It did tangle a little bit but I only brushed a few time throughout the day and I had on for a good 13 hours. Including human yaki lace wigs uk and brazilian human full lace wigs. Romance Curl Silk Top Glueless Full Lace Wig Fine Lace Wigs.