Mairim Russo Serafini, Daviane Maria Campos Vergne, Thallita Kelly Rabelo, Paula dos Passos Menezes, Ricardo Fagundes da Rocha, José Claudio Fonseca Moreira, Francilene Amaral da Silva, Péricles Barreto Alves, Hugo Cesar Ramos de Jesus, Adriano Antunes Souza Araújo, and Daniel Pens Gelain
E3 Journal of Biotechnology and Pharmaceutical Research Vol. 3(1), pp. 1-9, March 2012
Publication year: 2012
The aim of this study was therefore, to evaluate the redox properties of essential oil from H. pectinata (OEHP). TRAP/TAR assay indicated that OEHP is an antioxidant at 1 mg.mL-1. However, OEHP was not effective in preventing lipoperoxidation in vitro. Furthermore, OEHP reduced deoxyribose oxidative damage by hydroxyl radicals at 1 mg.mL-1 , but enhanced hydroxyl production from 1 ng.mL-1 to 10 µg.mL-1. Nitric oxide radical production was inhibited by OEHP at 1 µg.mL-1 to 1mg.mL-1. OEHP did not show any ability to scavenge superoxide radicals and hydrogen peroxide. The results of this study show that OEHP may act as an antioxidant or pro-oxidant depending on its concentration and which species they interact with. Thus, OEHP use for medicinal purposes must be taken with restrictions, and more assays to better determine its safety and biological effects are necessary.


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