Tâmara Coimbra Diniz , Tiago Coimbra Costa Pinto, Paula dos Passos Menezes, Juliane Cabral Silva, Roxana Braga de Andrade Teles, Rosana Christine Cavalcanti Ximenes, Adriana Gibara Guimarães, Mairim Russo Serafini, Adriano Antunes de Souza Araújo, Lucindo José Quintans Júnior & Jackson Roberto Guedes da Silva Almeida
Journal Expert Opinion on Therapeutic Patents Volume 28, 2018 - Issue 1, Pages 81-92
Publication year: 2017

Introduction: Depression is a serious mood disorder and is one of the most common mental illnesses. Despite the availability of several classes of antidepressants, a substantial percentage of patients are unresponsive to these drugs, which have a slow onset of action in addition to producing undesirable side effects. Some scientific evidence suggests that cyclodextrins (CDs) can improve the physicochemical and pharmacological profile of antidepressant drugs (ADDs). The purpose of this paper is to disclose current data technology prospects involving antidepressant drugs and cyclodextrins.

Areas covered: We conducted a patent review to evaluate the antidepressive activity of the compounds complexed in CDs, and we analyzed whether these complexes improved their physicochemical properties and pharmacological action. The present review used 8 specialized patent databases for patent research, using the term ‘cyclodextrin’ combined with ‘antidepressive agents’ and its related terms. We found 608 patents. In the end, considering the inclusion criteria, 27 patents reporting the benefits of complexation of ADDs with CDs were included.

Expert opinion: The use of CDs can be considered an important tool for the optimization of physicochemical and pharmacological properties of ADDs, such as stability, solubility and bioavailability.

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